When you must not take it
Do not take METHOBLASTIN if you have an allergy to:
- any medicine containing methotrexate
- any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
- shortness of breath
- wheezing or difficulty breathing
- swelling of the face, lips, tongue or other parts of the body
- rash, itching or hives on the skin.
Do not take the medicine if you have:
- severe kidney problems
- lowered immunity due to diseases such as HIV/AIDS or due to other treatments
- blood disorders, including Anaemia (low iron in the blood) and reduced number of red or white blood cells or platelets
- bone marrow disease
- severe liver disease
- stomach ulcers
Ulcerative colitis, inflammation of the bowel
- an infection
- an alcohol dependence (alcoholism).
Do not take the medicine if you are pregnant or trying to become pregnant.
Do not take the medicine if your partner is trying to become pregnant.
The medicine may cause birth defects if either you or your partner is taking it.
Do not take the medicine if you are breastfeeding.
It passes into the breast milk and may affect your baby.
Do not take this medicine if you are taking acitretin or etretinate, medicines used to treat Psoriasis and other skin conditions.
Do not use METHOBLASTIN after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.
Tell your doctor if you have or have had any of the following medical conditions:
- kidney problems
- liver problems
- lung problems
- folate deficiency
- lactose or galactose intolerance (Methoblastin tablets contain lactose).
Your doctor may do tests to check your blood, liver and kidneys.
Tell your doctor if you have an infection or high temperature.
Your doctor may decide to delay your treatment until the infection has gone. A mild illness, such as a cold, is not usually a reason to delay treatment.
Tell your doctor if you or your partner becomes pregnant while you are taking or just after you stop taking the medicine.
The medicine may cause birth defects if either the male or female partner is taking it. Use a proven method of birth control, such as the contraceptive pill or a condom, while taking the medicine and for at least 12 weeks after you stop treatment.
If you have not told your doctor about any of the above, tell them before you start using the medicine.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.
Some medicines and this medicine may interfere with each other. These include:
- aspirin and other pain relievers or anti-inflammatory medicines
- some antibiotics
- phenytoin, a medicine used to treat epilepsy
- sulfonylurea medicines used to treat diabetes
- diuretics, also known as fluid tablets
- probenecid, a medicine used to treat gout
- pyrimethamine, a medicine used to prevent malaria
- cholestyramine, a medicine used to lower blood Cholesterol levels
- theophylline, a medicine used to treat asthma
- azathioprine, a medicine used to prevent transplant organ rejection
- amiodarone, a medicine used to treat heart disorders
- leflunomide, a medicine used to treat rheumatoid arthritis
- sulfasalazine, a medicine used to treat Crohn's disease, Ulcerative colitis and rheumatoid arthritis
- retinoids, medicines used to treat skin conditions
- folic acid, a vitamin that may be present in multi-vitamin preparations (take your folic acid preparation on a another day of the week, separate from Methoblastin)
- some medicines used to treat cancers such as mercaptopurine, cisplatin, asparaginase
- methoxsalen, a medicine used with UV light (PUVA therapy) for skin conditions, such as severe psoriasis
- nitrous oxide anaesthesia
- packed red blood cells, blood transfusions.
Tell your doctor if you drink alcohol.
Alcohol may affect how well METHOBLASTIN works.
Your doctor has more information on medicines to be careful with or avoid while using this medicine.
Talk to your doctor if you are not sure whether you should be taking this medicine.